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          李闖創課題組完成高難度明星分子Vinigrol的最短全合成 近日,我?;瘜W系教授李闖創課題組在國際頂尖化學期刊《美國化學會志》(Journal of the American Chemical Society,簡稱JACS)發表論文,報道了明星天然產物Vinigrol的高效不對稱全合成。
          權澤衛課題組在《先進材料》發表重要研究進展 近日,南科大化學系教授權澤衛課題組在新型納米金屬間化合物領域取得最新進展,該成果發表在材料領域頂級期刊《先進材料》(Advanced Materials,IF:25.806)。
          化學系徐晶課題組在《美國化學會志》發表成重要進展 近日,徐晶課題組再次在復雜籠狀天然產物全合成領域取得重要進展,在《美國化學會志》發表重要研究論文,報道復雜籠狀虎皮楠生物堿Caldaphnidine O的國際首次全合成。
          化學系徐晶課題組在《美國化學會志》發表成果 近日,我?;瘜W系副教授徐晶課題組成功地完成了復雜虎皮楠生物堿Dapholdhamine B及其內酯衍生物的對映選擇性全合成工作,相關研究成果在《美國化學會志》(J. Am. Chem. Soc.)上發表。
          化學系劉心元課題組在自由基不對稱化學領域取得重要研究進展 近日,我?;瘜W系教授劉心元課題組在不對稱碳–碳鍵偶聯領域取得了重要研究進展。研究成果近期在《自然化學》(Nature Chemistry,IF:23.193)在線發表。
          化學系黃文忠課題組在《美國化學會志》發表最新研究成果 近日,我?;瘜W系副教授黃文忠課題組成功合成了一系列高發光強度的銠(III)配合物,并首次將其應用于有機電致發光二極管,取得重要研究進展。該成果在國際頂尖化學期刊《美國化學會志》
          化學系優秀畢業生
          優秀畢業生

          徐明華

          教授

          化學系

          0755-88018383

          xumh@sustech.edu.cn

          研究方向
          不對稱合成及手性藥物研究

          徐明華,浙江岱山人。1999年7月畢業于中國科學院上海有機化學研究所(導師:林國強研究員),獲得理學博士學位;同年8月赴美國,先后在美國弗吉尼亞大學(University of Virginia)化學系和喬治城大學醫學研究中心(Georgetown University Medical Center)從事博士后工作研究。20038月加入中國科學院上海有機化學研究所,2005年入選中國科學院“百人計劃”,7月起任中國科學院上海藥物研究所研究員、課題組長、博士生導師,新藥研究國家重點實驗室研究員。2018年受聘南方科技大學教授。


          主要從事有機不對稱合成及手性藥物方面的研究,致力于以一些重要有機分子及藥物分子合成為導向的手性化學和手性技術探索。近年來在新型手性配體和催化劑的設計以及生物活性分子合成和新藥研究等方面取得了一些有較大影響和創新性的研究成果。在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Acc. Chem. Res., Chem. Comm., Org. Lett.等國內外核心學術期刊上發表論文120余篇,多個工作受到國際國內同行的關注和好評,被美國化學會ACS “Heart Cut” (2),“Noteworthy Chemistry” (2),德國化學評論期刊Synfacts (32),英國Speciality Chemicals Magazine專欄,JACS Spotlights,Organic Chemistry Portal,X-MOL等選為研究亮點報道;10篇論文被選為期刊封面(其中1篇J. Am. Chem. Soc.封面);申請國內外專利24項,授權15項(美國專利2項)。應邀在國際性學術會議、海外知名大學作學術邀請報告100多次。


          曾獲中國化學會青年化學獎(2005),首屆藥明康德生命化學研究獎(2007),中國科學院朱李月華優秀教師獎(2012),中科院優秀研究生指導教師(2013),國家杰出青年科學基金(2013),上海市優秀學術帶頭人(2014),中國科學院特聘骨干研究員(2015),前沿有機化學亞洲核心計劃講座獎ACP Lectureship Award(日本3次、韓國、新加坡、泰國、臺灣),以及法國斯特拉斯堡大學邀請教授、日本九州大學“Global 30”計劃“Part-time Lecturer”、臺灣國科會化學促進中心訪問教授、日本北海道大學Hokkaido Summer Institute邀請教授等榮譽。2014年獲上海市自然科學一等獎。2016年獲國家自然科學二等獎(排名第二)。


          2018  深圳市國家級領軍人才

          2018  日本北海道大學Hokkaido Summer Institute特別邀請教授

          2018  《科學通報》編委

          2018  Elsevier開放期刊《Heliyon》編委

          2016  國家自然科學二等獎(第二完成人)

          2016  PERCH-CIC Congress IX: 2016 International Congress for Innovation in Chemistry, June 26-29, Pattaya, Thailand (Plenary Lecture)

          2016  客座編輯Tetrahedron Symposia-in-Print for “Chiral Sulfur Ligands/Catalysts in Asymmetric Catalysis”

          2015  中國科學院特聘研究員(骨干)

          2015  上海市研究生優秀學位論文指導教師

          2014  上海市自然科學一等獎(第二完成人)

          2014  亞洲核心計劃講座獎JSPS Asian Core Program Lectureship Award (Japan)

          2014  上海市優秀學術帶頭人

          2014  上海市研究生優秀學位論文指導教師

          2013  國家自然科學杰出青年基金

          2013  中國科學院優秀研究生指導教師

          2013  臺灣國科會化學促進中心訪問教授

          2013  日本九州大學(Kyushu University) 客座教授 (Part-Time Lecturer)

          2012  BOSS XIII (the 13th Belgian Organic Synthesis Symposium), July 15-20, 2012, Leuven, Belgium (Plenary Lecture)

          2012  中國科學院朱李月華優秀教師獎

          2011  法國斯特拉斯堡大學(Univ. of Strasbourg)邀請教授(Invited Professor)

          2010  亞洲核心計劃講座獎Asia Core Program Lectureship Award (Korea)

          2009  亞洲核心計劃講座獎Asia Core Program Lectureship Awards (Taiwan and Thailand)

          2008  亞洲核心計劃講座獎Asian Core Program Lectureship Award (Singapore)

          2008  上海市青年科技啟明星后

          2008  中科院上海分院杰出青年科技創新人才提名獎

          2007  亞洲核心計劃講座獎JSPS Asian Core Program Lectureship Award (Japan)

          2007  首屆藥明康德生命化學研究獎

          2006  亞洲核心計劃講座獎JAPS Asian Core Program Lectureship Award (Japan)

          2005  中國化學會青年化學獎

          2005  中國科學院“百人計劃”

          2005  上海市青年科技啟明星

          1、不對稱合成與手性藥物研究

          2、新型手性配體/催化劑的設計、合成以及在不對稱反應中的應用研究

          3、具重要生理活性的有機分子或藥物分子的高效合成以及反應方法學研究

          4、小分子藥物研究和發現

          1.  Yi Li, Bo Liu, and Ming-Hua Xu*, Rhodium-Catalyzed Enantioselective Alkenylation of Cyclic Ketimines: Practical Synthesis of Multifunctional Chiral α,α-Disubstituted Allylic Amine Derivatives”, Org. Lett. 2018, 20, 2306-2310. (Highlighted by Synfacts, 2018, 14(6), 0596)

          2.   Chun-Yan Wu, Yu-Fang Zhang, and Ming-Hua Xu*, “Ligand-Controlled Rhodium-Catalyzed Site-Selective Asymmetric Addition of Arylboronic Acids to α,b-Unsaturated Cyclic N-Sulfonyl Ketimines”, Org. Lett. 2018, 20, 1789-1793. (Highlighted by Synfacts, 2018, 14(6), 0597)

          3.  Zong-Fen Zhang, Dong-Xing Zhu, Wen-Wen Chen, Bin Xu* and Ming-Hua Xu*, “Enantioselective Synthesis of gem-Diaryl Benzofuran-3(2H)-ones via One-Pot Asymmetric Rhodium/Palladium Relay Catalysis”, Org. Lett. 2017, 19, 2726-2729. (Highlighted by Synfacts, 2017, 13(8), 0838, Abstracted by Organic Chemistry Portal)

          4. Tao Jiang, Wen-Wen Chen, and Ming-Hua Xu*, “Highly Enantioselective Arylation of N,N-Dimethylsulfamoyl-Protected Aldimines Using Simple Sulfur–Olefin Ligands: Access to Solifenacin and (S)-(+)-Cryptostyline II”, Org. Lett. 2017, 19, 2138-2141. (Highlighted by Synfacts, 2017, 13(7), 0720)

          5. Chun-Yan Wu, Yue-Na Yu, and Ming-Hua Xu*, “Construction of Chiral Tricyclic Indoles through a Rhodium-Catalyzed Asymmetric Arylation Protocol”, Org. Lett. 2017, 19, 384-387. (Highlighted by Synfacts, 2017, 13(3), 0298)

          6. Wen-Wen Chen, and Ming-Hua Xu*, “Rhodium Complex Catalysis in Asymmetric Synthesis of Heterocycles”, Org. Biomol. Chem. 2017, 15, 1029-1050. (Invited Review; Cover Article)

          7.  Xu Zhang, Bin Xu,* and Ming-Hua Xu*, “Rhodium-Catalyzed Asymmetric Arylation of N- and O-Containing Cyclic Aldimines: Facile and Efficient Access to Highly Optically Active 3,4-Dihydrobenzo[1,4]oxazin-2-ones and Dihydroquinoxalinones”, Org. Chem. Front. 2016, 3, 944-948. (Highlighted by Organic Chemistry Portal; Abstracted by ChemInform, 2016, 10.1002/chin.201648022)

          8.      Yu-Fang Zhang, Diao Chen, Wen-Wen Chen, and Ming-Hua Xu*, “Construction of Cyclic Sulfamidates Bearing Two gem-Diaryl Stereocenters through a Rhodium-Catalyzed Stepwise Asymmetric Arylation Protocol”, Org. Lett. 2016, 18, 2726-2729. (Highlighted by Synfacts, 2016, 12(8), 0837; Abstracted by ChemInform, 2016, 10.1002/chin.201644021)

          9.  Diao Chen, Dong-Xing Zhu, and Ming-Hua Xu*, “Rhodium(I)-Catalyzed Highly Enantioselective Insertion of Carbenoid into Si-H: Efficient Access to Functional Chiral Silanes”, J. Am. Chem. Soc. 2016, 138, 1498-1501. (Highlighted by Synfacts, 2016, 12(4), 0385; also highlighted at JACS journal homepage; Abstracted by ChemInform, 2016, 10.1002/chin.201630222; Top 1% highly cited paper in the field of Chemistry as of March/April 2017, data from ESI)

          10. Yi Li, Yue-Na Yu, and Ming-Hua Xu*, “Simple Open-Chain Phosphite-Olefin as Novel Ligand for Rh-Catalyzed Asymmetric Arylation of Cyclic Ketimines: Enantioselective Access to gem-Diaryl α-Amino Acid Derivatives”, ACS Catalysis, 2016, 6, 661-665. (Highlighted at ACS Catalysis journal homepage)

          11.    Diao Chen, Xu Zhang, Wei-Yi Qi, Bin Xu and Ming-Hua Xu*, “Rhodium(I)-Catalyzed Asymmetric Carbene Insertion into B-H Bonds Using Unprecedented C1-Symmetric Chiral Diene Ligand: Highly Enantioselective Access to Functionalized Organoboranes”, J. Am. Chem. Soc. 2015, 137, 5268-5271. (Cover Article, Featured in JACS Spotlights; Highlighted by Synfacts, 2015, 11(5), 0502; Abstracted by ChemInform, 2015, 10.1002/chin.201538189)

          12. Tao Jiang, Zheng Wang and Ming-Hua Xu*, “Rhodium-Catalyzed Asymmetric Arylation of Cyclic N-Sulfonyl Aryl Alkyl Ketimines:Efficient Access to Highly Enantioenriched α-Tertiary Amines”, Org. Lett. 2015, 17, 528-531. (Highlighted by Synfacts, 2015, 11(4), 0367; Abstracted by ChemInform, 2015, 10.1002/chin.201525171)

          13. Yi Li, and Ming-Hua Xu*, “Rhodium-Catalyzed Asymmetric Tandem Cyclization for Efficient and Rapid Access to Underexplored Heterocyclic Tertiary Allylic Alcohols Containing a Tetrasubstituted Olefin”, Org. Lett. 2014, 16, 2712- 2715. (Highlighted by Synfacts, 2014, 10(7), 0680; Abstracted by ChemInform, 2014, 10.1002/chin.201443089)

          14.    Yi Li, and Ming-Hua Xu*, “Simple Sulfur-Olefins as New Promising Chiral Ligands for Asymmetric Catalysis”, Chem. Commun. 2014, 50, 3771- 3782. (Invited Feature Article; Cover Article; Abstracted by ChemInform, 2014, 45, 22-025)

          15. Yi Li, Dong-Xing Zhu, and Ming-Hua Xu*, “A New Versatile Approach to Enantioenriched 3-Hydroxyoxindoles, 1,3-Dihydroisobenzofuran and 3-Isochromanone Derivatives by Rhodium-Catalyzed Asymmetric Arylation/Cyclization Sequence”, Chem. Commun. 2013, 49, 11659-11661. (Highlighted by Synfacts, 2014, 10(3), 0285; selected as an article of ChemComm Editor’s Choice; Abstracted by ChemInform, 2014, 45, 17-025)

          16. Hui Wang, Tao Jiang, and Ming-Hua Xu*, “Simple Branched Sulfur-Olefins as Chiral Ligands for Rh-Catalyzed Asymmetric Arylation of Cyclic Ketimines: Highly Enantioselective Construction of Tetrasubstituted Carbon Stereocenters”, J. Am. Chem. Soc. 2013, 135, 971-974. (Highlighted by Synfacts, 2013, 9(4), 0416; Abstracted by ChemInform, 2013, 44, 26-123; Top 1% highly cited paper in the field of Chemistry as of March/April 2017, data from ESI)

          17.  Shen-Shuang Jin, Hui Wang, Ting-Shun Zhu, and Ming-Hua Xu*, “Design of N-Cinnamyl Sulfinamides as New Sulfur-Containing Olefin Ligands for Asymmetric Catalysis: Achieving Structural Simplicity with a Categorical Linear Framework”, Org. Biomol. Chem. 2012, 10, 1764-1768. (Cover Article, highlighted on the OBC blog and also by Synfacts, 2012, 8(6), 0651; Abstracted by ChemInform, 2012, 43, 29-095; Featured in the top 10% of the most highly cited OBC articles published in the latest Impact Factor window (2011-2012))

          18. Ting-Shun Zhu, Shen-Shuang Jin, and Ming-Hua Xu*, “Rhodium-Catalyzed Highly Enantioselective 1,2-Addition of Arylboronic Acids to α-Ketoesters and α-Diketones Using Simple Chiral Sulfur-Olefin Ligands”, Angew. Chem. Int. Ed. 2012, 51, 780-783. (Highlighted by Synfacts, 2012, 8(4), 0422; Abstracted by ChemInform, 2012, 43, 23-023).

          19.    Shen-Shuang Jin, Hui Wang, and Ming-Hua Xu*, “Design of N-Sulfinyl Homoallylic Amines as Novel Sulfinamide-Olefin Hybrid Ligands for Asymmetric Catalysis: Application in Rh-Catalyzed Enantioselective 1,4-Additions”, Chem. Commun. 2011, 47, 7230-7232. (Highlighted by Synfacts, 2011, 9, 0985; Abstracted by ChemInform, 2011, 42, 44-025)

          20.    Zhi-Qian Wang, Chen-Guo Feng, Shu-Sheng Zhang, Ming-Hua Xu* and Guo-Qiang Lin*, “Rhodium-Catalyzed Asymmetric Conjugate Addition of Organoboronic Acids to Nitroalkenes Using Chiral Bicyclo[3.3.0] Diene Ligands”, Angew. Chem. Int. Ed., 2010, 49, 5780-5783. (Highlighted by Synfacts, 2010, 11, 1275 and Organic Chemistry Portal, 2011, July, 18; Abstracted by ChemInform, 2010, 41, 50-068)

          21. Guo-Qiang Lin,* Ming-Hua Xu, Yu-Wu Zhong and Xing-Wen Sun, “An Advance on Exploring N-tert-Butanesulfinyl -imines in Asymmetric Synthesis of Chiral Amines”, Acc. Chem. Res. 2008, 41, 831-840. (Abstracted by ChemInform, 2008, 39, 45-237; Top 1% highly cited paper in the field of Chemistry as of March/April 2017, data from ESI)

          22. Zhi-Qian Wang, Chen-Guo Feng, Ming-Hua Xu*, and Guo-Qiang Lin*, “Design of C2-Symmetric Tetrahydropentalenes as New Chiral Diene Ligands for Highly Enantioselective Rh-Catalyzed Arylation of N-Tosylarylimines with Arylboronic Acids”, J. Am. Chem. Soc. 2007, 129, 5336-5337. (Highlighted by Synfacts, 2007, 08, 0847 and Organic Chemistry Portal; Abstracted by ChemInform, 2007, 38, 37-073; Top 1% highly cited paper in the field of Chemistry as of March/April 2017, data from ESI).

          23.    Xing-Wen Sun, Ming-Hua Xu* and Guo-Qiang Lin*, “Room-Temperature Highly Diastereoselective Zn-Mediated Allylation of Chiral N-tert-Butanesulfinyl Imines: Remarkable Reaction Condition Controlled Stereoselectivity Reversal”, Organic Letters 2006, 8, 4979-4982. (Highlighted by Chemistry.Org of the American Chemical Society as a “Heart Cut” (Dec 4, 2006); also highlighted by Synfacts, 2006, 12, 1266; Abstracted by ChemInform, 2007, 38, 10-029).

          24. Yu-Wu Zhong, Yi-Zhou Dong, Kai Fang, Kenji Izumi, Ming-Hua Xu* and Guo-Qiang Lin*, “A Highly Efficient and Direct Approach for Synthesis of Enantiopure α-Amino Alcohols by Reductive Cross-Coupling of Chiral N-tert-Butanesulfinyl Imines with Aldehydes”, J. Am. Chem. Soc. 2005, 127, 11956-11957. (Highlighted by Synfacts, 2005, 3, 0331 and Organic Chemistry Portal; Abstracted by ChemInform, 2005, 37, 01-088).

          25. Yu-Wu Zhong, Ming-Hua Xu* and Guo-Qiang Lin, Samarium Diiodide-Induced Asymmetric Synthesis of Optically Pure Unsymmetrical Vicinal Diamines by Reductive Cross-Coupling of Nitrones with N-tert-Butanesulfinyl Imines. Organic Letters 2004, 6, 3953-3956. (Highlighted by Chemistry.Org of the American Chemical Society as a “Heart Cut” (Nov 15, 2004); also highlighted by Angew. Chem. Int. Ed. 2005, 44, 7833; Abstracted by ChemInform, 2005, 36, 06-080)


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